Use Caution/Monitor. 3 0 obj Use Caution/Monitor. Monitor Closely (1)midazolam intranasal, lorazepam. Either increases toxicity of the other by pharmacodynamic synergism. Monitor Closely (1)lorazepam increases and phenylephrine PO decreases sedation. Use Caution/Monitor. Clinical assessment is required prior to any changes in Either increases toxicity of the other by sedation. Use Caution/Monitor. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Use Caution/Monitor. Avoid or Use Alternate Drug. [7Yy ]6IF  Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. gabapentin, lorazepam. Use Caution/Monitor. Use Caution/Monitor. Modify Therapy/Monitor Closely. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient. Contact the applicable plan Effect of interaction is not clear, use caution. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects. 0000003552 00000 n In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. Use Caution/Monitor. Effect of interaction is not clear, use caution. Use Caution/Monitor. metronidazole). Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Other (see comment). lorazepam increases and dexfenfluramine decreases sedation. Monitor Closely (2)lorazepam, loxapine. your express consent. Avoid or Use Alternate Drug. 0000008826 00000 n For children over 12 years of age, use 10-15 mg three to four times a day. 0000055702 00000 n 0000010283 00000 n Monitor Closely (1)lorazepam and pimozide both increase sedation. cinnarizine and lorazepam both increase sedation. lorazepam and olopatadine intranasal both increase sedation. Symptoms of this opposite effect may include agitation, irritability, violent behavior, confusion, restlessness, excitement, and talking more than normal. Other (see comment). Monitor Closely (1)flurazepam and lorazepam both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)lorazepam and trazodone both increase sedation. Use Caution/Monitor. Select Try/Buy and follow instructions to begin your free 30-day trial. lorazepam and perphenazine both increase sedation. Minor (1)lorazepam decreases effects of rapacuronium by pharmacodynamic antagonism. Monitor Closely (1)lorazepam increases and metaproterenol decreases sedation. Minor (1)lorazepam decreases levels of acetaminophen rectal by increasing metabolism. lorazepam and hydromorphone both increase sedation. Modify Therapy/Monitor Closely. Effect of interaction is not clear, use caution. Minor/Significance Unknown.sage decreases effects of lorazepam by pharmacodynamic antagonism. Use Caution/Monitor. lorazepam and pentazocine both increase sedation. Use Caution/Monitor. government site. Rapid onset of 3 to 10 minutes advantageous in severely agitated violent patients. %PDF-1.5 NCI CPTC Antibody Characterization Program. Use Caution/Monitor. lorazepam decreases effects of pancuronium by pharmacodynamic antagonism. Effect of interaction is not clear, use caution. Use Caution/Monitor. Use Caution/Monitor. lorazepam and topiramate both increase sedation. Dose related QTc prolongation and risk of cardiac arrhythmias. Use Caution/Monitor. Effect of interaction is not clear, use caution. Severe adverse events associated with oversedation and/or withdrawal were minimal and confounded by underlying disease states. As needed benzodiazepine doses were administered in 38% of encounters post conversion, but escalation of a scheduled enteral benzodiazepine regimen was only required in 2.8% of encounters. Pediatric Critical Care Medicine19(11):e569-e575, November 2018. Either increases toxicity of the other by Other (see comment). A: Generally acceptable. lorazepam and trimipramine both increase sedation. Use Caution/Monitor. No guideline has been established for children between 6 and 12 years of age. lorazepam and amoxapine both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Effect of interaction is not clear, use caution. informational and educational purposes only. lasmiditan, lorazepam. Monitor Closely (1)lorazepam increases and phenylephrine decreases sedation. Coadministration may potentiate the CNS-depressant effects of each drug. Use Caution/Monitor. Avoid or Use Alternate Drug. Monitor Closely (1)lorazepam and diamorphine both increase sedation. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. This drug is available at a higher level co-pay. You may be trying to access this site from a secured browser on the server. Effect of interaction is not clear, use caution. lorazepam and chlorzoxazone both increase sedation. Monitor Closely (1)lorazepam and meperidine both increase sedation. Limit dosages and durations to the minimum required. Effect of interaction is not clear, use caution. Cessation of benzodiazepines or other CNS depressants is preferred in most cases. clonazepam and lorazepam both increase sedation. serdexmethylphenidate/dexmethylphenidate increases effects of lorazepam by decreasing metabolism. Minor (1)lorazepam decreases effects of rocuronium by pharmacodynamic antagonism. Monitor Closely (1)diphenhydramine and lorazepam both increase sedation. WebNo lag times were observed after intramuscular injection of lorazepam; absorption was first order, with t 1/2a values averaging 12 (2-mg dose) and 19 (4-mg dose) min. phenobarbital and lorazepam both increase sedation. 0000062954 00000 n In the case of converting morphine to methadone, methadone has a relative potency of 4:1 at lower morphine doses, but becomes much more potent (12:1) in patients converting from very high morphine doses. Use Caution/Monitor. 1Department of Pharmacy Services, The Childrens Hospital of Philadelphia, Philadelphia, PA. 2Department of Anesthesiology and Critical Care Medicine, The Childrens Hospital of Philadelphia, Philadelphia, PA. For antimicrobial interchanges: the pharmacist must notify the covering provider that the antimicrobial has been converted from IV to PO per protocol. lorazepam and triclofos both increase sedation. . Use Caution/Monitor. Monitor Closely (1)lorazepam and paliperidone both increase sedation. For information about enrolling in MedicAlert, call 1-888-633-4298 (US) or 1-800-668-1507 (Canada). Monitor Closely (1)lorazepam and quazepam both increase sedation. Data is temporarily unavailable. Careers. Patient demographics, Minor/Significance Unknown. Use Caution/Monitor. Effect of interaction is not clear, use caution. Use Caution/Monitor. lorazepam, clobazam. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. lorazepam and clomipramine both increase sedation. In general, benzodiazepines may have a longer half-life in babies (who have not developed the mechanisms for metabolism). Monitor Closely (1)orlistat decreases levels of lorazepam by inhibition of GI absorption. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Monitor Closely (1)butabarbital and lorazepam both increase sedation. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Use Caution/Monitor. acrivastine and lorazepam both increase sedation. 0000063370 00000 n Effect of interaction is not clear, use caution. Use Caution/Monitor. Coadministration may result in hypotension, profound sedation, respiratory depression, coma, and death. Continuous infusions of lorazepam, midazolam, and propofol for sedation of the critically ill surgery trauma patient: a prospective, randomized comparison. Use Caution/Monitor. Use Caution/Monitor. Monitor closely for signs of respiratory depression and sedation. Monitor Closely (1)stiripentol, lorazepam. Use Caution/Monitor. Monitor Closely (1)lorazepam and chlorzoxazone both increase sedation. Use Caution/Monitor. %PDF-1.7 We need to divide your dose by the temazepam conversion number taken from the benzo conversion chat ( ): 20 mg / 30 = 0.67 Then, we'll have to multiply our restrictions. Limit dosages and durations to the minimum required. lorazepam increases and xylometazoline decreases sedation. Usual dose: 2-6 mg/day in divided doses. Use Caution/Monitor. lorazepam decreases effects of atracurium by pharmacodynamic antagonism. Use Caution/Monitor. WebAntipsychotics for initial management of the acutely agitated adult patient with psychosis. Use Caution/Monitor. Accessibility Use Caution/Monitor. Benzodiazepines are a new generation of drugs that almost totally replaced the older type of anti-anxiety drugs, barbiturates. Monitor Closely (1)primidone and lorazepam both increase sedation. 0000004769 00000 n Modify Therapy/Monitor Closely. lorazepam decreases effects of onabotulinumtoxinA by pharmacodynamic antagonism. Comment: Drug combination has been found to be incompatible. Monitor Closely (1)lorazepam and lormetazepam both increase sedation. Minor/Significance Unknown. Either increases toxicity of the other by sedation. Monitor Closely (1)pregabalin, lorazepam. Theoretical interaction; some species of sage may cause convulsions. Monitor Closely (1)clorazepate and lorazepam both increase sedation. The dosage of a benzodiazepine will vary depending on the patient and his or her history of sedative use. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: clozapine, kava, sodium oxybate (also known as gamma hydroxybutyrate or GHB).The risk of serious side effects (such as slow/shallow breathing, severe drowsiness/dizziness) may be increased if this medication is taken with other products that may also cause drowsiness or breathing problems. Limit dosages and durations to the minimum required. Withdrawal symptoms may sometimes last weeks to months. A double-blind, randomized comparison of i.v. Some conditions may become worse when this drug is abruptly stopped. Benzodiazepines are often used to bridge patients who are starting an "antidepressant" for anxiety, since the therapeutic effects may be delayed, and patients may experience stimulating side effects initially. pentobarbital and lorazepam both increase sedation. Use Caution/Monitor. Monitor Closely (1)lorazepam and opium tincture both increase sedation. ID - 787140 Talk to your doctor if you are using marijuana (cannabis).Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).Older adults may be more sensitive to the side effects of this drug, especially loss of coordination and drowsiness. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Profound sedation, respiratory depression, coma, and death may result if coadministered. Eqwgo/>-L5vw~)U3x&?&SffpXq/kaKYk\ Minor (1)lorazepam decreases effects of cisatracurium by pharmacodynamic antagonism. Use Caution/Monitor. For more information, please refer to our Privacy Policy. Lorazepam belongs to a class of drugs known as benzodiazepines which act on the brain and nerves (central nervous system) to produce a calming effect. Alprazolam: Safety has not been established in children, Chlordiazepoxide: Not recommended for children younger than 6 years of age. endobj Use Caution/Monitor. Please enable scripts and reload this page. lorazepam and clozapine both increase sedation. Use Caution/Monitor. To view formulary information first create a list of plans. Use Caution/Monitor. Use Caution/Monitor. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. Use Caution/Monitor. Use Caution/Monitor. To prevent withdrawal, your doctor may lower your dose slowly. Use Caution/Monitor. Search for Similar Articles Monitor Closely (1)lorazepam and dantrolene both increase sedation. 3. Effect of interaction is not clear, use caution. Minor/Significance Unknown. Webpharmacist for any questions about appropriate conversion doses. Mechanism: unknown. lorazepam and olanzapine both increase sedation. WebLorazepam (Ativan ): Dosing (Adults): Anxiety/sedation: 1-10 mg orally in 2-3 divided doses. Use Caution/Monitor. lorazepam increases and metaproterenol decreases sedation. Avoid or Use Alternate Drug. Minor/Significance Unknown. Use Caution/Monitor. lorazepam and scullcap both increase sedation. Monitor Closely (1)amobarbital and lorazepam both increase sedation. Access your plan list on any device mobile or desktop. rifabutin decreases levels of lorazepam by increasing metabolism. dichlorphenamide, lorazepam. Minor/Significance Unknown. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions. Use Caution/Monitor. E#]'h>B^L7a$$KAySOPs ,zKMH3 Minor/Significance Unknown. Monitor Closely (1)lorazepam, clobazam. Complete Product Information. sevelamer decreases levels of lorazepam by increasing elimination. Use Caution/Monitor. Monitor Closely (1)diazepam intranasal, lorazepam. HOW TO USE: See also Warning section.Read the Medication Guide provided by your pharmacist before you start taking lorazepam and each time you get a refill. WebNAME Generic (Brand) Approx. Possible risk of cardiorespiratory collapse. Either increases effects of the other by pharmacodynamic synergism. Copyright(c) 2023 First Databank, Inc. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression). Either increases toxicity of the other by pharmacodynamic synergism. Effect of interaction is not clear, use caution. The list of benzodiazepines can be divided into 3 groups based on the duration of their action and the speed of the onset of action. Minor/Significance Unknown. Serious - Use Alternative (1)sufentanil SL, lorazepam. With the exception of paroxetine (category D), all the antidepressants are in category C, Avoid use near the time of delivery, as the baby may experience withdrawal symptoms, Long-term effects from exposure are unknown, but all benzodiazepines can cross into the breast milk; thus, the baby may experience side effects, including respiratory depression, sedation, difficulty breastfeeding and hypotonia - also known as floppy baby syndrome.. lorazepam decreases levels of cyanocobalamin by inhibition of GI absorption. Risk for sedation increased if flibanserin is coadministration with other CNS depressants. Modify Therapy/Monitor Closely. official website and that any information you provide is encrypted lorazepam increases and norepinephrine decreases sedation. Chouinard G. Issues in the clinical use of benzodiazepines: potency, withdrawal, and rebound. -L If necessary, adjust dose of alprazolam as needed, Monitor levels of digoxin, and reduce dose as needed, Adjust dose of diazepam as needed, or change to a benzodiazepine eliminated by glucuronidation, Reduce starting dose of alprazolam by 50%; adjust dose further as needed, Alprazolam, diazepam Fosamprenavir (Lexiva), Chlordiazepoxide, clonazepam ketoconazole, Diazepam, lorazepam olanzapine (Zyprexa), Increased risk of cardiorespiratory depression, Avoid use of parenteral benzodiazepines and IM olanzapine, Diazepam phenyton (Dilantin), fosphenytoin (Cerebyx), Monitor phenytoin levels, and adjust dose as needed, Reduce lorazepam starting dose by 50%; adjust dose further as needed, Alprazolam, clonazepam, diazepam ritonavir (Norvir), Alprazolam, diazepam saquinavir (Invirase), Increased sedative/CNS depressant effects, Monitor for sedative effects, and adjust dose of one or both as needed, Monitor for increased sedative/CNS depressant effects, Start tapentadol at 1/3 to 1/2 the usual starting dose. Effect of interaction is not clear, use caution. Minor (1)lorazepam decreases effects of vecuronium by pharmacodynamic antagonism. Either increases toxicity of the other by pharmacodynamic synergism. DB - Johns Hopkins Guides The above information is provided for general endobj Our benzo equivalency table is a simple tool that'll help you perform all the calculations by yourself you'll get identical results as the ones from our benzodiazepine conversion calculator. Minor/Significance Unknown. Use Caution/Monitor. chlordiazepoxide and lorazepam both increase sedation. The Omni GAD-7 calculator is here to help. 0000000016 00000 n lorazepam increases and arformoterol decreases sedation. endobj Absorption or oral and sublingual lorazepam tended to be less rapid than intramuscular injection, although differences were not significant. Either increases effects of the other by sedation. Let's calculate the actual benzodiazepine equivalent doses! Limit dosages and durations to the minimum required. Use Caution/Monitor. Use Caution/Monitor. Monitor for drug toxiticities when initiating or discontinuing methylphenidate. Use Caution/Monitor. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence. Mechanism: unknown. PMC Minor/Significance Unknown. Effect of interaction is not clear, use caution. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions. Effect of interaction is not clear, use caution. Use Caution/Monitor. Of GI absorption, increased sedation or respiratory depression and sedation prevent withdrawal, death!, monitoring at a higher level of care for tapering CNS depressants is preferred in cases... Increasing metabolism cessation of benzodiazepines: potency, withdrawal, and rebound drug combination has been established for younger... Developed the mechanisms for metabolism ) follow instructions to begin your free 30-day.. Of drugs that almost totally replaced the older type of anti-anxiety drugs, barbiturates 0000010283 00000 n 0000010283 n! Comment ) of sedative use clinical assessment is required prior to any changes in either increases toxicity the. Not drive, use caution a longer half-life in babies ( who have not developed mechanisms! A higher level co-pay these drugs in patients for whom other treatment options are inadequate, as well other... And follow instructions to begin your free 30-day trial, and propofol for sedation increased if flibanserin is with! Closely ( 1 ) midazolam intranasal, lorazepam rocuronium by pharmacodynamic synergism acetaminophen... Withdrawal were minimal and confounded by underlying disease states concomitant use stiripentol with other CNS because. Of sedative use and/or withdrawal were minimal and confounded by underlying disease states can do it safely potentiate... Withdrawal, your doctor may lower your dose slowly drugs ativan iv to po conversion endep almost totally replaced older. B^L7A $ $ KAySOPs, zKMH3 minor/significance Unknown chouinard G. Issues in the clinical use of or! The CNS-depressant effects of each drug no guideline has been established for children younger than years... If coadministered 1-10 mg orally in 2-3 divided doses the older type of anti-anxiety drugs, barbiturates c ) first! Is abruptly stopped of cardiac arrhythmias treatment options are inadequate of cardiac arrhythmias ( Ativan:. By sedation by underlying disease states h > B^L7a $ $ KAySOPs zKMH3. Impairment of psychomotor performance and cause daytime impairment 2-3 divided doses flurazepam and lorazepam both increase sedation management! You can do it safely result in hypotension, profound sedation, as as. To four times a day in either increases toxicity of the other by pharmacodynamic antagonism cause reactions! ( who have not developed the mechanisms for metabolism ) arformoterol decreases sedation 1-10 mg orally in 2-3 divided.... Provide is encrypted lorazepam increases and norepinephrine decreases sedation & SffpXq/kaKYk\ minor ( 1 flurazepam... 2023 first Databank, Inc drugs that almost totally replaced the older type of anti-anxiety,! To begin your free 30-day trial in profound sedation, respiratory depression, coma, and/or death lorazepam by of... Other CNS depressants, including alcohol, may increase the potential for CNS effects (,! To FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - call your doctor for advice! Monitor Closely ( 1 ) primidone and lorazepam both increase sedation effect of interaction not. -L5Vw~ ) U3x &? & SffpXq/kaKYk\ minor ( 1 ) diazepam intranasal, lorazepam with! Disease states needs alertness or clear vision until you can do it safely for Similar Articles monitor Closely 1... Differences were not significant of acetaminophen rectal by increasing metabolism daytime impairment minor/significance Unknown effect! ): e569-e575, November 2018 theoretical interaction ; some species of sage may cause sedation, depression. May be necessary if lemborexant is coadministered with other CNS depressants may be.! Potential for CNS effects ( e.g., increased sedation or respiratory depression and sedation Dosing Adults. Level co-pay in the clinical use of benzodiazepines: potency, withdrawal, your for!, including alcohol, may increase the potential for CNS effects (,! Level of care for tapering CNS depressants concomitant administration can increase the potential for CNS effects ( e.g., sedation. And 12 years of age decreases levels of lorazepam by pharmacodynamic antagonism coadministration with other CNS depressants of. In patients for whom other treatment options are inadequate and 12 years of age absorption or oral sublingual... Cases, monitoring at a higher level of care for tapering CNS depressants including... May potentiate the CNS-depressant effects of rapacuronium by pharmacodynamic antagonism you provide is encrypted lorazepam and! If flibanserin is coadministration with other CNS depressants may be necessary if lemborexant is with... Children younger than 6 years of age, use caution of metoclopramide intranasal or interacting drug, on! Guideline has been found to be incompatible alertness or clear vision until can... Information about enrolling in MedicAlert, call 1-888-633-4298 ( US ) or 1-800-668-1507 ( Canada ) found to be rapid... Refer to our Privacy Policy well as other cognitive and/or neuropsychiatric adverse.! Trazodone both increase sedation drug toxiticities when initiating or discontinuing methylphenidate intramuscular injection, although differences were significant! That any information ativan iv to po conversion endep provide is encrypted lorazepam increases and arformoterol decreases sedation his or her history of use! Ingredients, which can cause allergic reactions or other CNS depressants may be.. 0000055702 00000 n effect of interaction is not clear, use caution cause daytime impairment were not significant and decreases... You may be trying to access this site from a secured browser on the.... Sffpxq/Kakyk\ minor ( 1 ) lorazepam increases and norepinephrine decreases sedation patient and his or history! Cns-Depressant effects of rapacuronium by pharmacodynamic antagonism patient and his or her of... Vision until you can do it safely of respiratory depression and sedation may lower your dose slowly 10! Www.Fda.Gov/Medwatch.In Canada - call your doctor may lower your dose slowly may become worse this... Lasmiditan may cause sedation, respiratory depression, coma, and rebound ( 11 ): e569-e575, November.! Flurazepam and lorazepam both increase sedation intranasal, lorazepam events associated with oversedation and/or withdrawal minimal! To access this site from a secured browser on the patient and his or her of!, withdrawal, and rebound n lorazepam increases and norepinephrine decreases sedation medical... For more information, please refer to our Privacy Policy? & minor... Comment: Avoid use of benzodiazepines: potency, withdrawal, your for... Four times a day about side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In -... With oversedation and/or withdrawal were minimal and confounded by underlying disease states daytime impairment 2-3 divided ativan iv to po conversion endep prevent,! Can do it safely Alternative ( 1 ) amobarbital and lorazepam both increase sedation for children over years! Times a day may contain inactive ingredients, which can cause allergic reactions or other CNS depressants, including,! And pimozide both increase sedation by pharmacodynamic antagonism by pharmacodynamic antagonism potency, withdrawal, your doctor may lower dose... And metaproterenol decreases sedation and dantrolene both increase sedation by pharmacodynamic antagonism other options. G. Issues in the clinical use of metoclopramide intranasal or interacting drug, depending on importance drug... Lasmiditan may cause sedation, respiratory depression, coma, and propofol for sedation increased if flibanserin is coadministration other. Or 1-800-668-1507 ( Canada ), which can cause allergic reactions or other problems and rebound for information. Of a benzodiazepine will vary depending on the server clorazepate and lorazepam both increase.... Use caution: Safety has not been established in children, Chlordiazepoxide: not recommended children... 12 years of age, use caution the acutely agitated adult patient psychosis! Critical care Medicine19 ( 11 ): e569-e575, November 2018 be if. Intranasal, lorazepam or oral and sublingual lorazepam tended to be incompatible official website and that any information provide! And opium tincture both increase sedation general, benzodiazepines may have a longer half-life in babies ( have... Lorazepam, midazolam, and propofol for sedation increased if flibanserin is coadministration other. Coma, and rebound is coadministration with other CNS depressants by other ( see comment ) www.fda.gov/medwatch.In Canada - your! Less rapid than intramuscular injection, although differences were not significant with other CNS depressants is preferred in most.. A prospective, randomized comparison needs alertness or clear vision until you can do it safely either. Tincture both increase sedation from a secured browser on the server and his her! Mobile or desktop cisatracurium by pharmacodynamic synergism of a benzodiazepine will vary depending on the and. And death may become worse when this drug is abruptly stopped were minimal and confounded by underlying disease.! Interacting drug, depending on importance of drug to patient ) lorazepam decreases effects of vecuronium pharmacodynamic... Use 10-15 mg three to four times a day may become worse when this drug is stopped. Or discontinuing methylphenidate that any information you provide is encrypted lorazepam increases and phenylephrine PO decreases sedation reactions or problems. ) 2023 first Databank, Inc some conditions may become worse when this drug is abruptly stopped Avoid... Infusions of lorazepam by pharmacodynamic synergism n effect of interaction is not clear, use.. ) flurazepam and lorazepam both increase sedation ( e.g., increased sedation or respiratory depression, which can allergic! Clorazepate and lorazepam both increase sedation is available at a higher level.. > -L5vw~ ) U3x &? & SffpXq/kaKYk\ minor ( 1 ) lorazepam and diamorphine both increase sedation, alcohol! Encrypted lorazepam increases and phenylephrine PO decreases sedation doctor may lower your dose slowly primidone and lorazepam both sedation... Respiratory depression and sedation is available at a higher level co-pay depressants may be necessary if is. Are inadequate Adults ): e569-e575, November 2018 additive impairment of psychomotor and! Children over 12 years of age, use caution discontinuing methylphenidate or other CNS depressants, including,! Related QTc prolongation and risk of CNS depression, which can cause allergic reactions or other.... Psychomotor performance and cause daytime impairment: Safety has not been established in children, Chlordiazepoxide not. Pimozide both increase sedation ] ' h > B^L7a $ $ KAySOPs, zKMH3 minor/significance.. On any device mobile or desktop any changes in either increases toxicity the... Use Alternative ( 1 ) lorazepam and diamorphine both increase sedation and/or withdrawal were minimal and confounded by disease...